Quetiapine

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11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine

  • CAT Number DCTI-C-1686
  • CAS Number 5747-48-8
  • Molecular Formula C17H17N3S
  • Molecular Weight 295.4

N-Desalkyl quetiapine D8

  • CAT NUMBER DCTI-A-369
  • CAS NUMBER 1189866-35-0
  • MOLECULAR FORMULA C17H9D8N3S
  • MOLECULAR WEIGHT 303.45

Nitroso aryl piperazine

  • CAT NUMBER DCTI-C-2237
  • CAS NUMBER NA
  • MOLECULAR FORMULA C17H16N4OS
  • MOLECULAR WEIGHT 324.4

Nitroso aryl piperazine-D8

  • CAT NUMBER DCTI-A-286
  • CAS NUMBER NA
  • MOLECULAR FORMULA C17H8D8N4OS
  • MOLECULAR WEIGHT 332.45

Quetiapine Imp-A

  • CAT Number DCTI-C-1205
  • CAS Number 844639-07-2
  • Molecular Formula C23H27N3O3S
  • Molecular Weight 425.55

Quetiapine Imp-O

  • CAT Number DCTI-C-1506
  • CAS Number 844639-06-1
  • Molecular Formula C40H39N3O2S
  • Molecular Weight 625.83

Quetiapine Tetra Ethylene Glycol Fumarate Salt

  • CAT Number DCTI-C-1295
  • CAS Number 2470243-24-2
  • Molecular Formula C29H37N3O8S (Fumarate Salt) C25H33N3O4S (Free base)
  • Molecular Weight 587.69 (Fumarate Salt) 471.62 (Free base)

Quetiapine.HCl-D4

  • CAT Number DCTI-A-031
  • CAS Number 111974-69-7(Unlabelled)
  • Molecular Formula C21H22D4ClN3O2S (HCl Salt) C21H21D4N3O2S (Free base)
  • Molecular Weight 423.99 (HCl Salt) 387.53 (Free base)

General Information

Quetiapine Impurities and Quetiapine

Daicel Pharma offers high-quality Quetiapine impurity standards, including standards Quetiapine Imp-A, Quetiapine Imp-O, Quetiapine Tetra Ethylene Glycol Fumarate Salt, Nitroso aryl piperazine, and 11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine. Their presence can impact the effectiveness, stability, and safety of Quetiapine. Daicel Pharma provides custom Quetiapine impurities, ensuring worldwide delivery to cater to the unique requirements of our clients.

Quetiapine [CAS: 111974-69-7] is a N-alkylpiperazine, a dibenzothiazepine, and a N-arylpiperazine. Quetiapine is for treating various mental health conditions.

Quetiapine: Use and Commercial Availability

Quetiapine treats the symptoms of schizophrenia. Furthermore, it may be used as monotherapy or in combination with other medicines to treat acute manic or mixed episodes in people with bipolar l disorder, bipolar disorder, and major depressive disorder. It treats depressive episodes in people. This drug is available in the market under the brand name Seroquel.

Quetiapine Structure and Mechanism of ActionQuetiapine Structure and Mechanism of Action

The chemical name of Quetiapine is 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol. Its chemical formula is C21H25N3O2S, and its molecular weight is approximately 383.5 g/mol.

The mechanism of action of Quetiapine is not known.

Quetiapine Impurities and Synthesis

Quetiapine impurities are undesired compounds found in Quetiapine formulations that can occur during the synthetic process1 or manufacture or storage. They can impair Quetiapine’s quality, safety, and efficacy. As a result, stringent controls are put in place to identify, characterize, and manage impurities within permissible ranges.

Daicel Pharma offers a Certificate of Analysis (CoA) for Quetiapine impurity standards such as Quetiapine Imp-A, Quetiapine Imp-O, Quetiapine Tetra Ethylene Glycol Fumarate Salt, Nitroso aryl piperazine, and 11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine. Our cGMP-certified analytical laboratory provides the CoA, which includes thorough characterization data including 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. On request, we give more characterization details, such as those for 13C-DEPT. At Daicel Pharma, our team of experts specializes in synthesizing Quetiapine impurities and labeled compounds for evaluating the effectiveness of generic Quetiapine. Additionally, Daicel Pharma offers Quetiapine.HCl-D4 and Nitroso aryl piperazine-D8, deuterium-labeled Quetiapine compounds, crucial for bioanalytical research and Bioavailability/Bioequivalence (BA/BE) studies.

References
FAQ's

Frequently Asked Questions

All Quetiapine impurities are monitored strictly during the process.

Quetiapine impurities are examined during quality control testing by employing analytical techniques to identify and quantify the impurities present in the Quetiapine.

Quetiapine impurities are stored preferably at a regulated room temperature of 2-8°C or as specified on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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