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Home > Isotope Labelled Standards > Osimertinib

Osimertinib - Isotope Labelled Standards

Osimertinib-D6
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Osimertinib-D6

  • CAT Number DCTI-A-208
  • CAS Number 1638281-44-3
  • Molecular Formula C28H27D6N7O2
  • Molecular Weight 505.66
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References
FAQ's

References

  1. Rood, Johannes J. M. ; van Bussel, Mark T. J.; Schellens, Jan H. M.; Beijnen, Jos H.; Sparidans, Rolf W.,” Liquid chromatography-tandem mass spectrometric assay for the T790M mutant EGFR inhibitor osimertinib (AZD9291) in human plasma”, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, Volume: 1031, Pages: 80-85, 2016
  2. Rood, J. J. M.; van Haren, M. J.; Beijnen, J. H.; Sparidans, R. W., “Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry”, Journal of Pharmaceutical and Biomedical Analysis, Volume: 177, Pages: 112871, 2020
  3. Butterworth, Sam; Finlay, Maurice Raymond Verschoyle; Ward, Richard Andrew; Kadambar, Vasantha Krishna; Chandrashekar, Reddy C.; Murugan, Andiappan; Redfearn, Heather Marie, “2-(2,4,5-substituted-anilino) pyrimidine compounds”, AstraZeneca AB, Sweden, US8946235B2, Feb 3, 2015

Frequently Asked Questions

The most common impurities in Osimertinib are N-desmethyl Osimertinib, Osimertinib N-oxide, Osimertinib oxide, and Osimertinib desmethoxy.

Impurities in Osimertinib can potentially affect its stability, leading to drug degradation over time. It could affect the safety, efficacy, and shelf life of the drug.

Impurities in Osimertinib detection are through analytical methods such as high-performance liquid chromatography (HPLC), liquid chromatography mass spectrometry (LC-MS), etc.

Osimertinib impurities removal is by purification steps, such as crystallization or chromatography.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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