Methimazole - Isotope Labelled Standards
References
FAQ's
References
- Stenlake, John B.; Williams, William David; Skellern, G. G., Development and comparison of thin-layer chromatographic and gas-liquid chromatographic methods for measurement of methimazole in rat urine, Journal of Chromatography, Volume: 53, Issue: 2, Pages: 285-91, 1970 DOI: (1016/s0021-9673(01)98469-9)
- Skellern, G. G.; Knight, B. I.; Stenlake, J. B., Improved method for the determination of methimazole in plasma by high-performance liquid chromatography, Journal of Chromatography, Volume: 124, Issue: 2, Pages: 405-10, 1976 DOI: (10.1016/s0021-9673(00)89761-7)
Frequently Asked Questions
Which conditions cause the maximum degradation of Methimazole?
Oxidative hydrolytic conditions are responsible for the maximum degradation of Methimazole.
Which analytical techniques can identify the degradation products of Methimazole?
The ultraperformance liquid chromatography and Quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF MS/MS) techniques can identify the degradation products of Methimazole.
Why is it necessary to remove nitrosamine Methimazole impurities from the drug product?
Nitrosamine Methimazole impurities can be harmful to human health and may be carcinogenic. Hence, their removal from the drug is essential.
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