Verapamil - NDSRI's
References
FAQ's
References
- Basically substituted phenyl acetonitrile compounds, Knoll Akt.-Ges. Chemische Fabriken, Germany, US3261859A, July 19, 1966
- Harapat, Sandra R.; Kates, Robert E., Rapid high-pressure liquid chromatographic analysis of verapamil in blood and plasma, Journal of Chromatography, Volume: 170, Issue: 2, Pages: 385-90, 1979
Frequently Asked Questions
Why is it vital to regulate impurities in Verapamil?
Regulating impurities in Verapamil is crucial to maintain the drug's safety, effectiveness, and quality. They can impact the drug's potency, stability, and how it is absorbed in the body, potentially leading to adverse effects and reduced therapeutic outcomes.
How do impurities arise in Verapamil?
Impurities in Verapamil can form during manufacturing, storage, and transportation. They can originate from starting materials, intermediates, or by-products of chemical reactions.
What are the categories of impurities found in Verapamil?
Impurities found in Verapamil can be classified into several categories, which include process-related contaminants, degradation products, residual solvents, and genotoxic impurities.
How should Verapamil impurities be stored in terms of temperature?
The recommendation is to store Verapamil impurities at room temperature, within 2-8 °C.
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