Chlorpromazine - NDSRI's
References
FAQ's
References
- Charpentier, Paul, Phenthiazine derivatives, US2645640A, Dec 21, 1950, Societe des usines chimiques de Rhone-Poulenc (https://www.lens.org/lens/search/patent/list?q=US2645640)
- Curry, Stephen H., Determination of nanogram quantities of chlorpromazine and some of its metabolites in plasma by using gas-liquid chromatography with an electron capture detector, Analytical Chemistry, Volume: 40, Issue: 8, Pages: 1251-5, 1968, DOI: (10.1021/ac60264a031)
Frequently Asked Questions
2. How do we detect the degradation products of Chlorpromazine in the drug product?
Liquid chromatography-mass spectroscopy can detect the degradation products of Chlorpromazine in the drug product.
3. Which analytical method determines the presence of Chlorpromazine impurities in the drug substance?
A TLC-densitometric method is the analytical method that determines the presence of Chlorpromazine impurities in the drug substance.
4. Why is it necessary to eliminate nitrosamine impurities from Chlorpromazine?
Nitrosamine impurities are carcinogenic and affect drug safety. So, it is necessary to remove nitrosamine impurities from Chlorpromazine.
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