Pramipexole - NDSRI's
References
FAQ's
References
- Griss, Gerhart; Schneider, Claus; Hurnaus, Rudolf; Kobinger, Walter; Pichler, Ludwig; Bauer, Rudolf; Mierau, Joachim; Hinzen, Dieter; Schingnitz, Guenter, Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals, Thomae, Dr. Karl, G.m.b.H., Federal Republic of Germany, US4731374A, March 15, 1988
- Schneider, Claus S.; Mierau, Joachim, Dopamine autoreceptor agonists: resolution and pharmacological activity of 2,6-diaminotetrahydrobenzothiazole and an aminothiazole analog of apomorphine, Journal of Medicinal Chemistry, Volume: 30, Issue: 3, Pages: 494-8, 1987
- Bharathi, D. Vijaya; Hotha, Kishore Kumar; Sagar, P. V. Vidya; Kumar, S. Sirish; Naidu, A.; Mullangi, Ramesh, Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of pramipexole in human plasma: application to a clinical pharmacokinetic study, Biomedical Chromatography, Volume: 23, Issue: 2, Pages: 212-218, 2009
Frequently Asked Questions
How can impurities in Pramipexole be minimized?
Impurities in Pramipexole are minimized by using top-quality starting materials, reagents, and solvents and refining the manufacturing process. Additionally, it is crucial to maintain appropriate storage conditions to prevent impurities from forming.
Can impurities in Pramipexole affect its bioavailability?
Impurities in Pramipexole affect its bioavailability by altering its pharmacokinetics. For example, few impurities are more readily absorbed by the body than the API, leading to a change in drug concentration and efficacy.
Which solvent help in the analysis of Pramipexole impurities?
Methanol is the solvent used in analyzing many Pramipexole impurities.
What are the temperature conditions required to store Pramipexole impurities?
Pramipexole impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).
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