Promethazine - NDSRI's
References
FAQ's
References
- Cusic, John W., 8-Haloxanthine Salts Of Aminoalkyl Phenothiazines And The Production thereof, G.D. Searle and Co., US2534237A, December 19, 1950
- Hulshoff, Abram; Perrin, John H., Chromatographic characterization of phenothiazine drugs by a reversed-phase thin-layer technique, Journal of Chromatography, Volume: 129, Pages: 249-62, 1976
Frequently Asked Questions
How can Promethazine impurities be kept to a minimum while stored?
Proper storage of Promethazine from light, moisture, and extreme temperature, can reduce impurity accumulation over time. Following the manufacturer's or regulatory bodies' suggested storage parameters is critical to maintaining the drug's purity.
Are there specific Promethazine impurities that are common?
Impurities in Promethazine might vary based on the manufacturing process and starting ingredients. They include related compounds that might occur during synthesis, breakdown products, residual solvents, and handling or storage.
Can Promethazine impurities alter over time?
Promethazine's chemical makeup can degrade over time or combine with other chemicals causing new impurity formation. Proper Promethazine storage and handling can help reduce impurity formation and maintain the drug's stability.
What are the temperature conditions required to store Promethazine impurities?
Promethazine impurities are stored preferably at a regulated room temperature of 2-8°C or as specified on the Certificate of Analysis (CoA).
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