Acenocoumarol

General Information

Acenocoumarol Impurities and Acenocoumarol 

Daicel Pharma synthesizes high-quality Acenocoumarol impurities like (R)-Acenocoumarol and (S)-Acenocoumarol, which is crucial in analyzing the quality, stability, and biological safety of the active pharmaceutical ingredient Acenocoumarol. Moreover, Daicel Pharma offers custom synthesis of Acenocoumarol impurities and delivers them globally.

Acenocoumarol [CAS: 152-72-7] is a 4-hydroxycoumarin derivative, an anticoagulant medicine. It antagonizes vitamin K, similar to warfarin, and thus has anticoagulant properties. One advantage of using Acenocoumarol over other anticoagulants, such as warfarin and phenprocoumon, is the shorter duration of action, which is beneficial in case of bleeding.

Acenocoumarol: Use and Commercial Availability

Acenocoumarol is a medicine that treats and prevents thromboembolic diseases, including deep vein thrombosis, pulmonary embolism, cerebral embolism, and thromboembolism in infarction and transient ischemic attacks. In India, the drug is available under the trade names Acitrom and Nistrom.

Acenocoumarol Structure and Mechanism of Action

The chemical name of Acenocoumarol is 4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one. Its chemical formula is C₁₉H₁₅NO_6, and its molecular weight is approximately 353.3 g/mol.

Acenocoumarol inhibits Vitamin K reduction. It prevents carboxylation of glutamic acid residues, Vitamin K-dependent clotting factors.

Acenocoumarol Impurities and Synthesis

During the production of Acenocoumarol, impurities arise from the starting materials, synthetic process, or degradation of the drug substance. These impurities harm the drug’s safety and efficacy, hence monitoring and controlling the level of Acenocoumarol impurities is essential.

Daicel provides a Certificate of Analysis (CoA) for Acenocoumarol impurity standards, (R)-Acenocoumarol and (S)-Acenocoumarol. The CoA is issued from a cGMP-compliant analytical facility and contains complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity^1,2. Additional characterization data, such as 13C-DEPT and CHN, can be provided upon request. Daicel can also prepare any unknown Acenocoumarol impurity or degradation product and offer labeled compounds to quantify the efficacy of generic Acenocoumarol. Daicel offers Acenocoumarol-D5, a deuterium-labeled Acenocoumarol standard used in bio-analytical research, such as BA/BE studies. We give a complete characterization report on delivery.