Adenine

General Information

Adenine Impurities and Adenine 

Daicel Pharma synthesizes high-quality Adenine impurities like 2-Bromopropyl Adenine, 2-Chloropropyl Adenine, and 9-(2-Hydroxy ethyl) Adenine, which are crucial in the analysis of the quality, stability, and biological safety of the active pharmaceutical ingredient Adenine. Moreover, Daicel Pharma offers custom synthesis of Adenine impurities and delivers them globally.

Adenine [CAS: 73-24-5] is a purine nucleobase belonging to the class of 6-aminopurines. Adenine is the precursor of two important nucleosides, Adenosine, and deoxyadenosine. These nucleosides are crucial building blocks of DNA and RNA molecules, essential for the proper functioning of cells in living organisms.

Adenine: Use and Commercial Availability  

Adenine is a purine base organic compound that is an essential component of DNA and RNA. It is also present in many multivitamins and is used for nutritional supplementation to address dietary deficiencies or imbalances. Adenine is an active ingredient in many products, including Rejuvesol and CPDA-1.

Adenine Structure and Mechanism of Action

The chemical name of Adenine is 9H-Purin-6-amine. Its chemical formula is C₅H₅N₅, and its molecular weight is approximately 135.13 g/mol.

Adenine is a crucial component of Adenine nucleotides and forms Adenosine, a nucleoside when attached to ribose, and deoxyadenosine when attached to deoxyribose. It forms Adenosine triphosphate (ATP) when three phosphate groups add to Adenosine, and it helps in cellular metabolism by transferring chemical energy between chemical reactions.

Adenine Impurities and Synthesis

The impurities in Adenine are classified as organic and inorganic impurities. Organic impurities may include related substances such as Adenine analogs, while inorganic impurities may include heavy metals or other contaminants introduced during synthesis^1,2. Impurities can form during the synthesis, isolation, and purification of Adenine. The analysis and control of these impurities are essential to ensure that the final product meets the required quality standards for its intended use, whether for research, pharmaceuticals, or other applications.

Daicel provides a Certificate of Analysis (CoA) for Adenine impurity standards, including 2-Bromopropyl Adenine, 2-Chloropropyl Adenine, and 9-(2-Hydroxy ethyl) Adenine. The CoA is issued from a cGMP-compliant analytical facility and contains complete characterization data³, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity. Additional characterization data, such as 13C-DEPT and CHN, can be provided upon request. Daicel can also prepare any unknown Adenine impurity or degradation product. We give a complete characterization report on delivery.