Amsacrine

General Information

Amsacrine Impurities and Amsacrine

Daicel Pharma offers the best-quality Amsacrine impurities, such as Amsacrine 9,9′-oxydiacridine. They are vital for evaluating the quality, stability, and biological safety of Amsacrine. Furthermore, Daicel Pharma specializes in the custom synthesis of Amsacrine impurities and ensures their worldwide delivery.
Amsacrine [CAS: 51264-14-3] is a N-phenylmethanesulfonamide derivative. Further, it belongs to the aminoacridine family. It is an antineoplastic agent effective in acute leukemia treatment. Amsacrine (m-AMSA) binds to DNA and acts against topoisomerase II enzyme. It targets the adenosine–tyrosine pair of the DNA and prevents DNA synthesis.

Amsacrine: Use and Commercial Availability  

Amsacrine treats acute leukemias, Hodgkin’s, and non-Hodgkin’s lymphomas in adults. Further, it treats hematological cancers. As an anti-cancer drug, Amsacrine is effective against malignant lymphomas. It has approval for use as a cancer therapy in many countries. Amsacrine is available under various names such as Amsidyl, Amekrin, etc.

Amsacrine Structure and Mechanism of Action

The chemical name of Amsacrine is N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide. The chemical formula for Amsacrine is C₂₁H₁₉N₃O₃S, and its molecular weight is approximately 393.46 g/mol.

Amsacrine inhibits the topoisomerase II enzyme, causing DNA double-strand breaks. It stops the S/G2 phase of the cell cycle and results in cell death. Cytotoxicity is more during the S phase of the cell cycle, and the topoisomerase enzymes are at maximum levels.

Amsacrine Impurities and Synthesis

During the synthesis of Amsacrine 1, impurities may form that may affect the safety and efficacy of the drug. These impurities form during the synthesis, storage, or degradation of Amsacrine. As a result, Amsacrine impurities must be controlled and monitored throughout the drug development process.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Amsacrine impurities, which includes Amsacrine 9,9′-oxydiacridine. A cGMP-compliant analytical facility furnishes the CoA. It provides complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional spectral data on request. Daicel Pharma can prepare any unidentified Amsacrine impurity or degradation product. In addition, Daicel Pharma offers highly purified stable isotope-labeled standards of Amsacrine for bioanalytical research and BA/BE studies. Customers can expect a complete characterization report on delivery.