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Cabotegravir
References
FAQ's
References
- Johns, Brian Alvin; Kawasuji, Takashi; Taishi, Teruhiko; Taoda, Yoshiyuki, Bicyclic Carbamoylpyridone Derivative Having HIV Integrase Inhibiting Activity, Shionogi & Co., Ltd., Japan, EP1852434B1, July 13, 2011
- Krishna Murthy Kasa, S. R.; Venkatanarayana, Muvvala; Chennuru, Lakshmi Narayana; Chandra Sekhara Rao, B.; Vemparala, Manohar; Chaman, Abdul Fareed; Talluri, M. V. N. Kumar, Chiral LC method development: Stereo-selective separation, characterization, and determination of cabotegravir and related RS, RR, and SS isomeric impurities on coated cellulose-based chiral stationary phase by HILIC-LC and LC-MS, Journal of Pharmaceutical and Biomedical Analysis, Volume: 222, Pages: 115062, 2023
Frequently Asked Questions
How are impurities in Cabotegravir detected and analyzed?
Impurities in Cabotegravir are detected and analyzed using analytical techniques such as high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS). These techniques help in the identification and quantification of impurities.
How can Cabotegravir impurities affect the stability of the drug product?
Cabotegravir impurities can affect the stability of the drug product with an impact on the potency and efficacy of the drug. Controlling impurities is essential to ensure the stability and shelf-life of the drug product.
Which solvent helps in the analysis of Cabotegravir impurities?
Acetonitrile or Methanol are the solvents used for analyzing many impurities in Cabotegravir.
What are the temperature conditions required to store Cabotegravir impurities?
Cabotegravir impurities are stored at a controlled room temperature between 2-8 °C or as indicated on the Certificate of Analysis (CoA).
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