Candesartan

General Information

Candesartan Impurities and Candesartan 

Daicel Pharma offers excellent-quality Candesartan impurities, such as Candesartan N2-ethyl Benzimidazole Methyl Ester Impurity. They are vital for evaluating the quality, stability, and biological safety of Candesartan. Furthermore, Daicel Pharma specializes in the custom synthesis of Candesartan impurities and ensures their worldwide delivery.

Candesartan [CAS: 139481-59-7] is a benzimidazole carboxylic acid derivative. It is an angiotensin-receptor blocker that treats hypertension. Candesartan relaxes the blood vessels and prevents the onset of atrial fibrillation. It has a prodrug, candesartan cilexetil.

Candesartan: Use and Commercial Availability  

Candesartan is available as Atacand, an oral formulation. It is an antihypertensive agent used alone or with other antihypertensive agents. Further, it treats heart failure in adults with left ventricular systolic dysfunction. Candesartan reduces cardiovascular death. It prevents migraine and manages diabetic renal disease in patients.

Candesartan Structure and Mechanism of Action

The chemical name of Candesartan is 2-Ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid. The chemical formula for Candesartan is C24H20N6O3, and its molecular weight is approximately 440.45 g/mol.

Candesartan selectively blocks the binding of angiotensin II to AT1 receptors in tissues like the adrenal gland and vascular smooth muscles. It prevents the vasoconstrictor properties of angiotensin II receptors.

Candesartan Impurities and Synthesis

During Candesartan synthesis1, impurities form that may affect the safety and efficacy of the drug. They form during the synthetic process, purification, or storage of Candesartan. And so, Candesartan impurities must be controlled and monitored throughout the drug’s development process.

Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Candesartan impurities, which includes Candesartan N2-ethyl Benzimidazole Methyl Ester Impurity. Daicel Pharma offers CoA from a cGMP-compliant analytical facility. It provides complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional analytical data on request. Daicel Pharma can prepare any unidentified Candesartan impurity or degradation product. In addition, Daicel Pharma offers a highly purified, stable deuterium-labeled standard, Candesartan Labelled Standard. The clients of Daicel Pharma can expect a complete characterization report on delivery.