Chlorpromazine

General Information

Chlorpromazine Impurities and Chlorpromazine 

Daicel Pharma is a reliable source in synthesizing excellent-quality Chlorpromazine impurities, such as Chlorpromazine Impurity – F. They are vital for evaluating the quality, stability, and biological safety of Chlorpromazine. Furthermore, Daicel Pharma specializes in the custom synthesis of Chlorpromazine impurities and ensures their global delivery.

Chlorpromazine [CAS: 50-53-3] is a first-generation antipsychotic drug. It is a phenothiazine derivative that is a dopaminergic antagonist. Its antiemetic properties are due to inhibiting dopamine receptors in the medullary chemoreceptor trigger zone (CTZ) in the human brain.

Chlorpromazine: Use and Commercial Availability  

Chlorpromazine treats Schizophrenia and Bipolar I acute manic disorder. As an antiemetic, it controls nausea and vomiting. Further, it controls preoperative apprehension in patients undergoing surgery. It also treats intractable hiccups. Many generic manufacturers prepare Chlorpromazine under brands such as Thorazine, Sonazine, Promapar, etc. It is available under various strengths, routes, and formulations.

Chlorpromazine Structure and Mechanism of Action

The chemical name of Chlorpromazine is 2-Chloro-N, N-dimethyl-10H-phenothiazine-10-propanamine. The chemical formula for Chlorpromazine is C17H19ClN2S, and its molecular weight is approximately 318.87 g/mol.

Chlorpromazine post-synaptic blocks D2 receptors in the mesolimbic pathway in the brain.

Chlorpromazine Impurities and Synthesis

During Chlorpromazine synthesis1, impurities form that may affect the safety and efficacy of the drug. They form during the synthetic process, purification, or storage of Chlorpromazine. Chlorpromazine impurities must be controlled and monitored throughout the drug development process.

Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Chlorpromazine impurities, which includes Chlorpromazine Impurity – F. Daicel Pharma offers CoA from a cGMP-compliant analytical facility. It provides complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional analytical data on request. Daicel Pharma can prepare any unidentified Chlorpromazine impurity or degradation product. In addition, Daicel Pharma offers a highly purified, stable isotope-labeled standard of Chlorpromazine. The clients of Daicel Pharma can expect a complete characterization report on delivery.