Ciprofloxacin

General Information

Ciprofloxacin Impurities and Ciprofloxacin 

Daicel Pharma is a reliable source in synthesizing and offering high-quality Ciprofloxacin impurities, including ethyl 7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate. These impurities are essential for evaluating the quality, stability, and safety of Ciprofloxacin, which is an active pharmaceutical ingredient. Additionally, Daicel Pharma offers a customized synthesis of Ciprofloxacin impurities for global delivery to meet the specific needs of our customers.

Ciprofloxacin [CAS: 85721-33-1] is a fluoroquinolone medicine. It is an antibiotic that treats bacterial infections in the body. It acts against gram-negative bacteria like Escherichia coli, Salmonella spp., etc. Ciprofloxacin treats pseudomonas aeruginosa bacterial infections in patients. Ciprofloxacin works against pathogens and is resistant to antibiotics.

Ciprofloxacin: Use and Commercial Availability  

Ciprofloxacin treats and prevents several bacterial infections. As a broad-spectrum antibiotic, it treats urinary tract infections, skin and soft tissue infections, pneumonia, typhoid fever, gastrointestinal infections, lower respiratory tract infections, sexually transmitted infections, eye and ear infections, and more. It is available in various formulations. Further, many manufacturers market Ciprofloxacin under brands such as Cipro, Ciloxan, Cetraxal, Otiprio, etc.

Ciprofloxacin Structure and Mechanism of Action

The chemical name of Ciprofloxacin is 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. The chemical formula for Ciprofloxacin is C17H18FN3O3, and its molecular weight is approximately 331.34 g/mol.

Ciprofloxacin interferes with the enzyme DNA gyrase, which is responsible for bacterial DNA synthesis. It blocks bacterial DNA topoisomerase, thus preventing DNA replication.

Ciprofloxacin Impurities and Synthesis

When synthesizing Ciprofloxacin1, the formation of impurities may affect drug safety and efficacy. They form during the synthetic process, storage, or purification of Ciprofloxacin. Ciprofloxacin impurities need controlling and monitoring for better drug safety, potency, and storage.

Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Ciprofloxacin impurities, which includes ethyl 7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate. A CoA is from a cGMP-compliant analytical facility. It has complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional spectral data on request. Daicel Pharma can prepare any unidentified Ciprofloxacin impurity or degradation product. In addition, Daicel Pharma offers highly purified, stable isotope-labeled standards of Ciprofloxacin. Accompanying the delivery will be a complete characterization report.