Cortexolone

General Information

Cortexolone Impurities and Cortexolone

Daicel Pharma offers high-quality Cortexolone impurities such as Cortexolone 21-propionate. It is vital for evaluating Cortexolone’s quality, stability, and biological safety. Furthermore, Daicel Pharma specializes in the custom synthesis of Cortexolone impurities and ensures their worldwide delivery.

17,21-Dihydroxypregn-4-ene-3,20-dione, known as cortexolone [CAS: 152-58-9], is a 17-hydroxycorticosteroid exhibiting glucocorticoid and anti-inflammatory properties. It serves as an intermediate in the biosynthesis of cortisol in the adrenal gland.

Cortexolone: Use and Commercial Availability

Cortexolone is a derivative of cortisol, a topical androgen antagonist that treats acne. It functions as a metabolite in both mice and humans. Cortexolone is classified as a glucocorticoid and falls into categories including primary alpha-hydroxy ketones, tertiary alpha-hydroxy ketones, and deoxycortisol.

Cortexolone Structure and Mechanism of Action

Cortexolone is also known as 11-Deoxycortisol. The chemical formula for Cortexolone is C₂₁H₃₀O₄, and its molecular weight is approximately 346.5g/mol.

The exact mechanism of action of Cortexolone is not known.

Cortexolone Impurities and Synthesis

While synthesizing Cortexolone, care is crucial to maintain the drug’s purity and efficacy. Despite these efforts, impurities can emerge, potentially impacting the drug’s quality. Sophisticated purification techniques such as chromatography and crystallization can minimize impurities. Continuous monitoring and adherence to stringent quality standards are essential in Cortexolone synthesis.

Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Cortexolone impurities, such as Cortexolone 21-propionate. The CoA is from a cGMP-compliant analytical facility and encompasses complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC² purity. On request, we give additional data like 13C-DEPT and CHN. Daicel Pharma prepares any unidentified Cortexolone impurity or degradation product. Furthermore, Daicel Pharma offers highly purified isotope-labeled standards of Cortexolone for bioanalytical research and BA/BE studies. We provide a complete characterization report upon delivery.