Cromolyn

General Information

Cromolyn Impurities and Cromolyn  

Daicel Pharma is a reliable source in synthesizing excellent-quality Cromolyn impurities, such as Cromolyn Tricarboxylic acid analog. They are vital for checking Cromolyn’s quality, stability, and biological safety. Furthermore, Daicel Pharma specializes in the custom synthesis of Cromolyn impurities and ensures their global delivery.

Cromolyn [CAS: 16110-51-3] is a bis-chromone derivative of glycerol. Also known as Cromoglicate, it treats asthma, both allergic and exercise-induced. It prevents the release of inflammatory mediators, histamines, and leukotrienes. In addition, it treats conjunctivitis, allergic rhinitis, and ulcerative colitis.

Cromolyn: Use and Commercial Availability  

Cromolyn treats allergic rhinitis, bronchial asthma, and other allergic eye conditions like keratitis and keratoconjunctivitis. Further, it treats systemic mastocytosis in patients. Cromolyn also prevents and relieves nasal allergies, hay fever symptoms, etc. Drug manufacturers sell Cromolyn in various formulations such as metered spray, oral, ophthalmic solutions, etc. Cromolyn is available under Crolom, Cromoptic, Gastrocom, Intal, Nasalcrom, Opticrom, etc.

Cromolyn Structure and Mechanism of Action

The chemical name of Cromolyn is 5,5′-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid]. The chemical formula for Cromolyn is C23H16O11, and its molecular weight is approximately 468.37 g/mol.

Cromolyn decreases intracellular calcium accumulation. It reduces pulmonary mast cell degranulation. Further, it prevents histamine release and inflammatory leukotrienes.

Cromolyn Impurities and Synthesis

During Cromolyn synthesis1, impurities form that may affect the safety and efficacy of the drug. They form during the synthetic process, purification, or storage of Cromolyn. Controlling and monitoring of Cromolyn impurities is necessary throughout the drug development process.

Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Cromolyn impurities, which includes Cromolyn Tricarboxylic acid analog. Daicel Pharma offers CoA from a cGMP-compliant analytical facility. It provides complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional analytical data on request. Daicel Pharma can prepare any unidentified Cromolyn impurity or degradation product. In addition, Daicel Pharma offers a highly purified, stable isotope-labeled Cromolyn standard. The clients of Daicel Pharma can expect a complete characterization report on delivery.