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Dexmedetomidine
References
FAQ's
References
- Karjalainen, Arto Johannes; Virtanen, Raimo Einari; Savolainen, Eino Juhani, Optical Isomers Of An Imidazole Derivative, Farmos-Yhtyma Oy, Finland, GB2206880B, April 24, 1991
- Hui, Y.-H.; Marsh, K. C.; Menacherry, S., Analytical method development for the simultaneous quantitation of dexmedetomidine and three potential metabolites in plasma, Journal of Chromatography A, Volume: 762, Issue: 1 + 2, Pages: 281-291, 1997
- Ji, Qin C.; Zhou, Julie Y.; Gonzales, R. John; Gage, Eric M.; El-Shourbagy, Tawakol A., Simultaneous quantitation of dexmedetomidine and glucuronide metabolites (G-Dex-1 and G-Dex-2) in human plasma utilizing liquid chromatography with tandem mass spectrometric detection, Rapid Communications in Mass Spectrometry, Volume: 18, Issue: 15, Pages: 1753-1760, 2004
Frequently Asked Questions
What is the significance of impurity control in Dexmedetomidine?
Dexmedetomidine impurities help ensure the drug's quality, safety, and efficacy. Controlling impurities help maintain the desired pharmacological properties, reduces the risk of adverse effects, and ensures compliance with regulatory standards.
How are Dexmedetomidine impurities analyzed?
Impurities in Dexmedetomidine are analyzed using various analytical techniques such as chromatography (HPLC, LC), spectroscopy (UV, IR), mass spectrometry (MS), and other advanced methods. These techniques help in the identification, quantification, and characterization of impurities.
Which solvent helps in the analysis of Dexmedetomidine impurities?
Methanol and Water are the solvents used in analyzing many impurities in Dexmedetomidine.
What are the temperature conditions required to store Dexmedetomidine impurities?
Dexmedetomidine impurities are stored at a controlled room temperature between 2-8 °C or as indicated on the Certificate of Analysis (CoA).
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