Furosemide

General Information

Furosemide Impurities and Furosemide

Daicel Pharma offers excellent-quality Furosemide impurities, such as Furosemide Metabolite and NDSRI of Furosemide impurity-A. They are vital for evaluating Furosemide quality, stability, and biological safety. In addition, Daicel Pharma specializes in the custom synthesis of Furosemide impurities and ensures worldwide delivery.
Furosemide [CAS: 54-31-9] is an anthranilic acid derivative and a diuretic. It blocks the sodium-chloride co-transport system. It results in water excretion along with sodium, magnesium, chloride, calcium, potassium, and hydrogen ions. It has vasodilatory properties that are effective in treating pulmonary edema. The two metabolites of Furosemide include Furosemide glucuronide and 4-chloro-5-sulfamoylanthranilic acid.

Furosemide: Use and Commercial Availability 

Furosemide affects the kidneys, leading to increased water loss from the body. It treats patients suffering from edema due to congestive heart failure, nephrotic syndrome, and liver cirrhosis. It combines with other anti-hypertensive medicines to treat hypertension. Many manufacturers prepare Furosemide in various formulations and brands. Furosemide is available under the brands Lasix and Furoscix. The route of Furosemide drug administration is oral or intravenous.

Furosemide Structure and Mechanism of Action

The chemical name of Furosemide is 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid. The chemical formula for Furosemide is C₁₂H₁₁ClN₂O₅S, and its molecular weight is approximately 330.75 g/mol.

Furosemide stops sodium and chloride absorption in the proximal and distal tubules and the Henley’s loop of the kidneys.

Furosemide Impurities and Synthesis

During Furosemide synthesis, impurities form that may affect the safety and efficacy of the drug. They form during the synthetic process, purification, or storage of Furosemide. And so, Furosemide impurities must be controlled and monitored throughout the drug development.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Furosemide impurities, which includes Furosemide Metabolite and NDSRI of Furosemide impurity-A. We provide the CoA from a cGMP-compliant analytical facility. It gives complete characterization data^1,2 such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity³. We provide additional analytical data on request. Daicel Pharma can prepare any unidentified Furosemide impurity or degradation product. In addition, Daicel Pharma offers highly purified, stable isotope-labeled standards of Furosemide. The clients of Daicel Pharma can expect a complete characterization report on delivery.