Gliclazide

General Information

Gliclazide Impurities and Gliclazide

Daicel Pharma offers superior-quality Gliclazide impurities and labeled standards. It is vital for evaluating Gliclazide quality, stability, and biological safety. Further, Daicel Pharma excels in the custom synthesis of Gliclazide impurities and ensures their global delivery.
Gliclazide [CAS: 21187-98-4] is a N-sulfonylurea derivative. It is a hypoglycemic agent that lowers blood glucose levels in the human body. It improves insulin secretion in type 2 diabetic patients. Further, it has antioxidant and antiplatelet properties.

Gliclazide: Use and Commercial Availability

Gliclazide treats patients with non-insulin-dependent diabetes mellitus (NIDDM)with diet and exercise. It manages blood sugar levels in type 2 diabetic patients and prevents the progression of diabetic microangiopathy. It is available in different formulations under various brands such as Diamicron, Edicil, Zicron, Nazdol, etc.

Gliclazide Structure and Mechanism of Action

The chemical name of Gliclazide is 1-(4-Methylbenzenesulfonyl)-3-[octahydrocyclopenta[c]pyrrol-2-yl]urea. The chemical formula for Gliclazide is C₁₅H₂₁N₃O₃S. Its molecular weight is approximately 323.41 g/mol.

Gliclazide inhibits the ATP-sensitive potassium channels after binding to the beta cell sulfonylurea receptor. It decreases potassium efflux and beta-cell depolarization. It further opens voltage-dependent calcium channels in the beta cells, causing exocytosis of insulin-containing secretory granules.

Gliclazide Impurities and Synthesis

When synthesizing Gliclazide 1, the formation of impurities may affect drug safety and efficacy. They form during the synthetic process, storage, or purification of Gliclazide. With continuous control and monitoring of Gliclazide impurities, manufacturers can ensure the drug is safe, effective, and stable.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Gliclazide impurities and labeled standards. The offered CoA is from a cGMP-compliant analytical facility with complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional spectral data on request. Daicel Pharma can prepare any unidentified Gliclazide impurity or degradation product. In addition, Daicel Pharma offers a highly purified, stable deuterium-labeled standard, Gliclazide Labelled Standard. A complete characterization report accompanies the delivery.