Glycocholic

General Information

Glycocholic acid Impurities and Glycocholic acid

Daicel Pharma offers excellent-quality Glycocholic acid impurities, such as Glycine 6-ethylchenodeoxy cholate Impurity, Glycoursodeoxy cholic acid, Glycochenodeoxy cholic acid, and Ursochenodiol Impurity. They are vital for evaluating Glycocholic acid quality, stability, and biological safety. In addition, Daicel Pharma specializes in the custom synthesis of Glycocholic acid impurities and ensures worldwide delivery.
Glycocholic acid [CAS: 475-31-0] is a bile acid component of human bile. It is the glycine conjugate of cholic acid. In mammals, it is present as a sodium salt in the bile Cholic acid, a primary bile acid, combines with glycine to form Glycocholic acid through the N-acylase transferase process. Defects in this N-acylation process of cholic acid result in severe liver diseases diagnosed by Glycocholic acid.

Glycocholic acid: Use and Commercial Availability

Glycocholic acid emulsifies fats for absorption in the body. It is available as oral formation. It treats children and adolescents with inborn bile acid metabolism errors. Glycocholic acid helps in fat-soluble vitamin absorption and improves the growth of the affected children and adolescents. It has many medicinal uses. Further, it has anti-cancer properties.

Glycocholic acid Structure and Mechanism of Action

The chemical name of Glycocholic acid is N-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycine. The chemical formula for Glycocholic acid is C₂₆H₄₃NO₆, and its molecular weight is approximately 465.62 g/mol.

The precise mechanism of action of Glycocholic acid and its anion, glycocholate, is unclear.

Glycocholic acid Impurities and Synthesis

During Glycocholic acid synthesis, impurities form that may affect the safety and efficacy of the drug. They form during the synthetic process, purification, or storage of Glycocholic acid. Hence, Glycocholic acid impurities need continuous control and monitoring throughout the drug development.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Glycocholic acid impurities, which includes Glycine 6-ethylchenodeoxy cholate Impurity, Glycoursodeoxy cholic acid, Glycochenodeoxy cholic acid, and Ursochenodiol Impurity. We provide the CoA from a cGMP-compliant analytical facility. It gives complete characterization data1,2, like 1H NMR, 13C NMR, IR, MASS, and HPLC purity. We provide additional analytical data on request. Daicel Pharma can prepare any unidentified Glycocholic acid impurity or degradation product. In addition, Daicel Pharma offers highly purified, stable isotope-labeled standards of Glycocholic acid. The clients of Daicel Pharma can expect a complete characterization report on delivery.