Guaifenesin

General Information

Guaifenesin Impurities and Guaifenesin

Daicel Pharma offers excellent-quality Guaifenesin impurities, such as EPO Dimer Impurity. They are vital for evaluating Guaifenesin quality, stability, and biological safety. In addition, Daicel Pharma specializes in the custom synthesis of Guaifenesin impurities and ensures worldwide delivery.
Glyceryl guaiacolate, or Guaifenesin [CAS: 93-14-1] is an expectorant. It improves cough reflex efficiency and helps reduce its viscosity. It removes accumulated secretions from the upper and lower airway. Guaifenesin belongs to the adrenergic antagonist class of medicines. It improves sinus and bronchial drainage.

Guaifenesin: Use and Commercial Availability

Guaifenesin is available in different oral formulations under brands such as Mucinex, Allfen, Altarussin, Benylin, etc. It treats cough discomfort by acting as an expectorant. Further, it acts as a muscle relaxant with mild sedative activity. It is used alone or combined with other antihistamines and decongestants. It helps manage cough in patients suffering from common colds, bronchitis, influenza, and other respiratory diseases.

Guaifenesin Structure and Mechanism of Action

The chemical name of Guaifenesin is 3-(2-Methoxyphenoxy)-1,2-propanediol. The chemical formula for Guaifenesin is C₁₀H₁₄O₄, and its molecular weight is approximately 198.22 g/mol.

Guaifenesin increases secretions in the trachea and bronchi and reduces its viscosity.

Guaifenesin Impurities and Synthesis

During Guaifenesin synthesis, impurities form that may affect the safety and efficacy of the drug. They form during the synthetic process, purification, or storage of Guaifenesin. And so, Guaifenesin impurities must be controlled and monitored throughout the drug development.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Guaifenesin impurities, which includes EPO Dimer Impurity. We provide the CoA from a cGMP-compliant analytical facility. It gives complete characterization data1,2 such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity3. We provide additional analytical data on request. Daicel Pharma can prepare any unidentified Guaifenesin impurity or degradation product. In addition, Daicel Pharma offers highly purified, stable isotope-labeled standards of Guaifenesin. The clients of Daicel Pharma can expect a complete characterization report on delivery.