Hydrochlorothiazide

General Information

Hydrochlorothiazide Impurities and Hydrochlorothiazide

Daicel Pharma offers excellent-quality Hydrochlorothiazide impurities, such as Hydroxy Impurity. They are vital for evaluating Hydrochlorothiazide quality, stability, and biological safety. In addition, Daicel Pharma specializes in the custom synthesis of Hydrochlorothiazide impurities and ensures worldwide delivery.
Hydrochlorothiazide [CAS: 58-93-5] is a chlorothiazide derivative. It is a diuretic and antihypertensive agent. It reduces blood pressure causing vasodilation and decreasing peripheral vascular resistance.

Hydrochlorothiazide: Use and Commercial Availability

Hydrochlorothiazide treats hypertension and peripheral edema. As a diuretic, it helps in urine excretion due to its effects on the kidneys. Further, it combines with many angiotensin-converting enzyme inhibitors. It supplements other drugs to treat edema in patients with congestive heart failure, estrogen and corticosteroid therapy, and hepatic cirrhosis. Hydrochlorothiazide is available as oral formulations under brands Esidrix, Hydrodiuril, Microzide, Oretic, etc.

Hydrochlorothiazide Structure and Mechanism of Action

The chemical name of Hydrochlorothiazide is 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. The chemical formula for Hydrochlorothiazide is C₇H₈ClN₃O₄S₂, and its molecular weight is approximately 297.74 g/mol.

Hydrochlorothiazide inhibits sodium and chloride ions reabsorption in the distal convoluted tubules of kidneys. It causes an ionic imbalance, leading to the opening of the voltage-gated channels. It decreases calcium and uric acid excretion and reduces the glomerular filtration rate.

Hydrochlorothiazide Impurities and Synthesis

During Hydrochlorothiazide synthesis1, impurities form that may affect the safety and efficacy of the drug. They form during the synthetic process, purification, or storage of Hydrochlorothiazide. And so, Hydrochlorothiazide impurities must be controlled and monitored throughout the drug development.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Hydrochlorothiazide impurities, which includes Hydroxy Impurity. We provide the CoA from a cGMP-compliant analytical facility. It gives complete characterization data2 such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity. We provide additional analytical data on request. Daicel Pharma can prepare any unidentified Hydrochlorothiazide impurity or degradation product. In addition, Daicel Pharma offers highly purified, stable isotope-labeled standards of Hydrochlorothiazide. The clients of Daicel Pharma can expect a complete characterization report on delivery.