Iodixanol

General Information

Iodixanol Impurities and Iodixanol

Daicel Pharma offers excellent-quality Iodixanol impurities, such as Iodixanol Impurity-1 (Mixture of Isomers). They are vital for evaluating Iodixanol quality, stability, and biological safety. Furthermore, Daicel Pharma specializes in the custom synthesis of Iodixanol impurities and ensures their worldwide delivery.
Iodixanol [CAS: 92339-11-2] is an iodinated x-ray contrast agent. It is a dimeric, hydrophilic compound that is useful for diagnostic imaging. It helps to view blood vessels and organs on a CT scan. Further, it aids in diagnosing disorders of the brain, heart, kidneys, etc.

Iodixanol: Use and Commercial Availability

During coronary angiography, Iodixanol acts as a contrast agent. As it is less toxic to kidneys, it helps patients with renal dysfunction. It is for CECT imaging of the head and body. Iodixanol visualizes the aorta and its branches to diagnose arterial occlusive diseases, tumors, and aneurysms. The route of drug administration is intravenous or intra-arterial. Iodixanol is available under brands Visipaque 270 and Visipaque 320 as injectable formulations.

Iodixanol Structure and Mechanism of Action

The chemical name of Iodixanol is 5,5′-[(2-Hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N, N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide. The chemical formula for Iodixanol is C₃₅H₄₄I₆N₆O₁₅, and its molecular weight is approximately 1550.18 g/mol.

Iodixanol opacifies or makes opaque the vessels that are in the path of the flow of the contrast agent. It allows radiographic visualization of the internal organs until noteworthy dilution and elimination occurs.

Iodixanol Impurities and Synthesis

Impurities form during Iodixanol synthesis1 that may affect the safety and efficacy of the drug. These impurities develop during the manufacturing process, purification, or storage of Iodixanol. Therefore, the control and monitoring of Iodixanol impurities is essential throughout the drug development.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Iodixanol impurities, which includes Iodixanol Impurity-1 (Mixture of Isomers). We provide the CoA from a cGMP-compliant analytical facility. It gives complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We provide additional analytical data on request. Daicel Pharma can prepare any unidentified Iodixanol impurity or degradation product. In addition, Daicel Pharma offers highly purified, stable isotope-labeled standards of Iodixanol. We guarantee a complete characterization report on delivery.