Isosulfan Blue

General Information

Isosulfan blue Impurities and Isosulfan blue

Daicel Pharma offers excellent-quality Isosulfan blue impurities, such as Isosulfan Blue Impurity 1. They are vital for evaluating Isosulfan blue quality, stability, and biological safety. Furthermore, Daicel Pharma specializes in the custom synthesis of Isosulfan blue impurities and ensures their worldwide delivery.
Isosulfan blue [CAS: 68238-36-8] aids in detecting cancer cells. It is a sulfan blue structural isomer. It is a synthetic lymphatic imaging agent. As a colored dye, Isosulfan blue helps visually detect lymphatic nodes. It stains lymphatic channels before lymphangiography.

Isosulfan blue: Use and Commercial Availability

As an imaging agent, Isosulfan blue delineates lymphatic vessels. It is a dye for lymphatic mapping of sentinel lymph node biopsy in patients with endometrial, cervical, and breast cancer. Isosulfan blue also helps in the lymphatic mapping of melanoma. It supplements lymphography in primary and secondary lymphedema of the extremities. Isosulfan blue is available as Lymphazurin for subcutaneous administration.

Isosulfan blue Structure and Mechanism of Action

The chemical name of Isosulfan blue is N-[4-[[4-(diethylamino)phenyl](2,5-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl- Ethanaminium sodium salt. The chemical formula for Isosulfan blue is C₂₇H₃₂N₂O₆S₂. Na. Its molecular weight is approximately 567.68 g/mol.

Isosulfan blue at the periphery of the tumor site localizes to the lymphatic system and helps surgically identify tumor sentinel nodes stained blue.

Isosulfan blue Impurities and Synthesis

Impurities form during Isosulfan blue synthesis1 and may affect the drug’s safety and efficacy. These impurities develop during the manufacturing process, purification, or storage of Isosulfan blue. Therefore, the control and monitoring of Isosulfan blue impurities is essential throughout the drug development.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Isosulfan blue impurities, which includes Isosulfan Blue Impurity 1. We provide the CoA from a cGMP-compliant analytical facility. It gives complete characterization data2 such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity. We provide additional analytical data on request. Daicel Pharma can prepare any unidentified Isosulfan blue impurity or degradation product. In addition, Daicel Pharma offers highly purified, stable isotope-labeled standards of Isosulfan blue. We guarantee a complete characterization report on delivery.