Istradefylline

General Information

Istradefylline Impurities and Istradefylline

Daicel Pharma offers superior-quality Istradefylline impurities, such as Istradefylline Impurity. These impurities are essential for evaluating Istradefylline quality, stability, and biological safety. In addition, Daicel Pharma specializes in the custom synthesis of Istradefylline impurities and ensures their worldwide delivery.
Istradefylline [CAS: 155270-99-8] blocks adenosine A2A receptor activity, helping adult patients with Parkinson’s disease. It is a fused pyrimidine derivative with antiparkinsonian effects. It was first developed by Kyowa Hakko Kirin, Japan. It is considered as an alternative medicine to dopaminergic drugs.

Istradefylline: Use and Commercial Availability

Istradefylline is used with levodopa/carbidopa in patients with Parkinson’s disease who have motor fluctuations, such as dyskinesia and hallucinations. It helps improve the quality of life of these patients. The US FDA approved it in 2019. Istradefylline is available as an oral formulation under Nourianz and Nouryant.

Istradefylline Structure and Mechanism of Action

The chemical name of Istradefylline is 8-[(1E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione. The chemical formula for Istradefylline is C₂₀H₂₄N₄O₄, and its molecular weight is approximately 384.43 g/mol.

Istradefylline inhibits the activity of adenosine A2A receptors found on some brain cells, controlling movement. It reduces overactive striatopallidal output and GABAergic activity.

Istradefylline Impurities and Synthesis

While synthesizing Istradefylline 1, impurities may form that will affect drug safety and efficacy. They form during the synthetic process, storage, or purification of Istradefylline. Manufacturers can control and monitor Istradefylline impurities to improve the drug’s safety, efficacy, and storage.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Istradefylline impurities, which includes Istradefylline Impurity. The CoA provided to clients is from a cGMP-compliant analytical facility with the complete characterization data2 such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity. We give additional spectral data on request. Daicel Pharma can prepare any unidentified Istradefylline impurity or degradation product. In addition, Daicel Pharma offers highly purified, stable isotope-labeled standards of Istradefylline. Daicel Pharma provides a complete characterization report accompanying the delivery.