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Lenvatinib
References
FAQ's
References
- Funahashi, Yasuhiro; Tsuruoka, Akihiko; Matsukura, Masayuki; Haneda, Toru; Fukuda, Yoshio; Kamata, Junichi; Takahashi, Keiko; Matsushima, Tomohiro; Miyazaki, Kazuki; Nomoto, Kenichi; et al, Nitrogenous Aromatic Ring Compounds As Anti Cancer Agents, EP1415987B1, February 28, 2007
- Mano, Yuji; Kusano, Kazutomi, A validated LC-MS/MS method of total and unbound lenvatinib quantification in human serum for protein binding studies by equilibrium dialysis, Journal of Pharmaceutical and Biomedical Analysis, Volume: 114, Pages: 82-87, 2015
Frequently Asked Questions
How do impurities form in Lenvatinib?
Impurities in Lenvatinib can form during the manufacturing process, storage conditions, or due to interactions with other components. Factors such as temperature, pH, and exposure to light can contribute to impurity formation.
What are the acceptable limits for Lenvatinib impurities?
Regulatory authorities, such as the United States Pharmacopeia (USP) or the International Council for Harmonization (ICH), provide guidelines on acceptable limits for impurities in Lenvatinib to ensure its safety and quality.
Can Lenvatinib impurities affect its efficacy or safety?
Impurities in Lenvatinib have the potential to impact its efficacy or safety. Some may have toxic effects or alter the drug's therapeutic properties, making it crucial to control them within acceptable limits.
How should Lenvatinib impurities be stored in terms of temperature?
The recommendation is to store Lenvatinib impurities at a controlled room temperature, within 2-8 °C.
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