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Linezolid
References
FAQ's
References
- Barbachyn, Michael R.; Brickner, Steven J.; Hutchinson, Douglas K., Substituted Oxazine And Thiazine Oxazolidinone Antimicrobials, Upjohn Co., United States,EP717738B1, October 20, 1999
- Brickner, Steven J.; Hutchinson, Douglas K.; Barbachyn, Michael R.; Manninen, Peter R.; Ulanowicz, Debra A.; Garmon, Stuart A.; Grega, Kevin C.; Hendges, Susan K.; Toops, Dana S, Synthesis and Antibacterial Activity of U-100592 and U-100766, Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections, Journal of Medicinal Chemistry, Volume: 39, Issue: 3, Pages: 673-9, 1996
- Peng, Geoffrey W.; Stryd, Ronald P.; Murata, Shoiji; Igarashi, Mayumi; Chiba, Koji; Aoyama, Hiroyuki; Aoyama, Makiko; Zenki, Tomoko; Ozawa, Naoki, Determination of linezolid in plasma by reversed-phase high-performance liquid chromatography, Journal of Pharmaceutical and Biomedical Analysis, Volume: 20, Issue: 1-2, Pages: 65-73, 1999
Frequently Asked Questions
Can Linezolid impurities vary from batch to batch?
Yes, the presence and levels of impurities in Linezolid can vary from batch to batch due to variations in the process, raw materials, and other factors. However, manufacturers aim to maintain consistent quality and minimize impurity levels within acceptable limits.
Are there specific methods used to detect and quantify Linezolid impurities?
Yes, analytical methods such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS) are commonly employed to detect and quantify impurities in Linezolid. These methods allow for accurate assessment and control of impurity levels.
Which solvent helps in analyzing Linezolid impurities?
Methanol is a solvent used when analyzing many impurities in Linezolid.
What is the recommended storage temperature for Linezolid impurities?
Linezolid impurities should be stored, at a controlled room temperature, usually between 2-8 °C.
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