Loratadine

General Information

Loratadine Impurities and Loratadine

Daicel Pharma offers high-quality Loratadine impurities, such as Methanone.HCl Regio isomer. They are vital for evaluating Loratadine quality, stability, and biological safety. Furthermore, Daicel Pharma specializes in the custom synthesis of Loratadine impurities and ensures their worldwide delivery.

Loratadine [CAS: 79794-75-5], an azatadine derivative, is an antihistamine. It treats and manages allergic rhinitis and urticaria. Loratadine is a non-sedating, long-acting tricyclic histamine H1-receptor antagonist. It is a second-generation antihistamine with anti-allergic properties.

Loratadine: Use and Commercial Availability

Loratadine is a piperidine derivative and a US FDA-approved drug. It treats allergic rhinitis and allergic skin rashes. It provides relief to patients suffering from seasonal allergies. At present, Loratadine is an OTC (over-the-counter) drug. It is administered orally to patients. There are many generic manufacturers of Loratadine. Loratadine is available as Alavert, Claritin, Claritin Reditabs, Claritin Redidose, Claritin Hives Relief, and more.

Loratadine Structure and Mechanism of Action

The chemical name of Loratadine is Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate. The chemical formula for Loratadine is C₂₂H₂₃ClN₂O₂ and its molecular weight is approximately 382.88 g/mol.

Loratadine blocks histamine H1-receptors present in respiratory smooth muscle cells. It causes a reduction in vascular permeability in various cells.

Loratadine Impurities and Synthesis

During the synthesis of Loratadine¹, impurities may form that may affect the safety and efficacy of the drug. These impurities form during the synthesis, storage, or degradation of Loratadine. As a result, impurities must be controlled and monitored throughout the drug’s lifecycle.

Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Loratadine impurities, which includes Methanone.HCl Regio isomer. The CoA is from a cGMP-compliant analytical facility and encompasses complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². We give additional data like 13C-DEPT and CHN on request. Daicel Pharma can prepare any unidentified Loratadine impurity or degradation product. In addition, Daicel Pharma offers highly purified isotope-labeled standards of Loratadine for bioanalytical research and BA/BE studies. We also provide a complete characterization report on delivery.