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Methotrexate
References
FAQ's
References
- Catalucci, Enrico, Process for the production of methotrexate, Lonza A.-G., Switzerland, US4224446A, September 23, 1980
- Chatterji, Dulal C.; Gallelli, Joseph F., High-pressure liquid chromatographic analysis of methotrexate in presence of its degradation products, Journal of Pharmaceutical Sciences Volume: 66, Issue: 9, Pages: 1219-22, 1977
Frequently Asked Questions
Are there specific tests performed to identify Methotrexate impurities?
Yes, specific tests are conducted to identify impurities in Methotrexate. Analytical methods such as high-performance liquid chromatography (HPLC), liquid chromatography (LC), or mass spectrometry (MS) help separate and detect impurities in the drug.
Can Methotrexate impurities be removed through purification processes?
Purification processes can help reduce impurities in Methotrexate. Techniques such as recrystallization, filtration, or chromatography are used during manufacturing to remove impurities and improve the drug's purity.
Which solvent helps in analyzing Methotrexate impurities?
DMSO is the solvent used when analyzing many impurities in Methotrexate.
What is the recommended storage temperature for Methotrexate impurities?
Methotrexate impurities should be stored, at a controlled room temperature, usually between 2-8 °C.
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