Metoclopramide

General Information

Metoclopramide Impurities and Metoclopramide

Daicel Pharma offers the best-quality Metoclopramide impurities, such as 4-amino-3-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide. They are vital for evaluating Metoclopramide quality, stability, and biological safety. Furthermore, Daicel Pharma specializes in the custom synthesis of Metoclopramide impurities and ensures their worldwide delivery.

Metoclopramide [CAS: 364-62-5] is a dopamine receptor antagonist. It is a drug approved by the US FDA for treating nausea and vomiting in patients with gastroesophageal reflux disease or diabetic gastroparesis. It increases gastric motility in patients.

Metoclopramide: Use and Commercial Availability  

Metoclopramide treats patients with gastroesophageal reflux disease. It relieves symptoms associated with symptomatic gastroesophageal reflux. Further, it treats symptoms connected with acute and recurrent diabetic gastroparesis. Metoclopramide is available as an oral formulation under brands such as Metozolov ODT. In addition, it is available as a nasal spray under Gimoti. Further, its parenteral administration controls nausea and vomiting in chemotherapy patients.

Metoclopramide Structure and Mechanism of Action

The chemical name of Metoclopramide is 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide. The chemical formula for Metoclopramide is C₁₄H₂₂ClN₃O2, and its molecular weight is approximately 299.80 g/mol.

Metoclopramide blocks the stimulation of the medullary chemoreceptor trigger zone (CTZ) by L-dopa or apomorphine. These agents increase dopamine levels, which produces nausea. It also blocks the antiperistaltic effects of apomorphine, causing slowing of gastric emptying.

Metoclopramide Impurities and Synthesis

During the synthesis of Metoclopramide, impurity formation may affect the drug’s safety and efficacy. These impurities form during the manufacturing process, purification, or storage of Metoclopramide. Therefore, Metoclopramide impurities must be controlled and monitored throughout the drug’s development.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Metoclopramide impurities, which includes 4-amino-3-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide. We provide the CoA from a cGMP-compliant analytical facility. It gives complete characterization data1such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We provide additional analytical data on request. Daicel Pharma can prepare any unidentified Metoclopramide impurity or degradation product. In addition, Daicel Pharma offers a highly purified, stable deuterium-labeled standard, Metoclopramide Labelled Standard. We provide a complete characterization report to clients on delivery.