Nadolol

General Information

Nadolol Impurities and Nadolol

Daicel Pharma offers superior-quality Nadolol impurities, such as N-Nitroso-Nadolol. These impurities are essential for evaluating Nadolol quality, stability, and biological safety. In addition, Daicel Pharma specializes in the custom synthesis of Nadolol impurities and ensures their worldwide delivery.

Nadolol [CAS: 42200-33-9] is a β- adrenergic receptor blocker that treats high blood pressure in patients. It has long-term use in managing angina pectoris. It blocks the effect of catecholamine on β-1 receptors. Its beta-blocking activity can block isoproterenol-induced tachycardia.

Nadolol: Use and Commercial Availability  

Nadolol manages hypertension, angina, and various cardiovascular diseases. Cardiovascular diseases include stroke, heart failure, and coronary heart disease. In addition, it helps in lowering free thyroid hormone levels in the bloodstream. It improves thyrotoxicosis symptoms in patients. It also helps in preventing migraine headaches. It also aids patients with liver cirrhosis. Nadolol is available as an oral formation under Corgard.

Nadolol Structure and Mechanism of Action

The chemical name of Nadolol is 5-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-2,3-naphthalenediol. The chemical formula for Nadolol is C₁₇H₂₁NO₄, and its molecular weight is approximately 309.40 g/mol.

Nadolol stops the β-1 receptors in the vascular smooth muscles and heart. It decreases peripheral vascular resistance and lowers systolic and diastolic blood pressure.

Nadolol Impurities and Synthesis

While synthesizing Nadolol 1, impurities may form that will affect drug safety and efficacy. They form during the synthetic process, storage, or purification of Nadolol. Manufacturers can control and monitor Nadolol impurities to improve the drug’s safety, efficacy, and storage.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Nadolol impurities, which includes D N-Nitroso-Nadolol. The CoA given to clients is from a cGMP-compliant analytical facility, which has the complete characterization data2 such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity. We give additional spectral data on request. Daicel Pharma can prepare any unidentified Nadolol impurity or degradation product. In addition, Daicel Pharma offers a highly purified, stable deuterium-labeled standard, Nadolol Labelled Standard. Daicel Pharma provides a complete characterization report accompanying the delivery.