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Octreotide
References
FAQ's
References
- Wilflried Bauer, Lampenberg; Janos Pless, Sandoz Ltd, “Novel Polypeptides, Processes For Their Production, Pharmaceutical Compositions Comprising Said Polypeptides And Their Use” US patent, US 4,395,403, July 26, 1983
- Edwards, W. Barry; Fields, Cynthia G.; Anderson, Carolyn J.; Pajeau, Tammy S.; Welch, Michael J.; Fields, Gregg B., “Generally Applicable, Convenient Solid-Phase Synthesis and Receptor Affinities of Octreotide Analogs” Journal of Medicinal Chemistry, Volume: 37, Issue: 22, Pages: 3749-57,1994
Frequently Asked Questions
How are impurities removed from Octreotide?
Octreotide impurities are removed through a combination of purification techniques, such as chromatography, crystallization, and filtration.
How are Octreotide impurities identified?
Octreotide impurities are identified using analytical techniques such as high-performance liquid chromatography (HPLC), and liquid chromatography-mass spectrometry (LC-MS).
How are Octreotide impurities synthesized?
The synthesis of Octreotide impurities involves the use of various chemical reactions, such as peptide coupling, esterification, and protection/deprotection steps.
What is the impact of impurities on Octreotide?
Impurities can have a significant impact on the safety, efficacy, and stability of Octreotide. They can affect the drug's pharmacological properties, increase the risk of adverse reactions, and reduce the shelf life of the drug.
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