Pazopanib

General Information

Pazopanib Impurities and Pazopanib 

Daicel Pharma offers Pazopanib impurity standards, including Pazopanib Dimer, Pazopanib Impurity 9, Pazopanib impurity 8, Pazopanib N-oxide (RRT-0.70), Pazopanib Pyrimidine impurity and more. The impurities can impact the efficacy, stability, and safety of Pazopanib. Daicel Pharma can synthesize custom Pazopanib impurities and delivers them worldwide.

Pazopanib [CAS: 444731-52-6] is a pyrimidine derivative treating kidney cancer. Pazopanib acts as an antineoplastic agent, a tyrosine kinase inhibitor, a vascular endothelial growth factor receptor antagonist, and an angiogenesis-modulating agent.

Pazopanib: Use and Commercial Availability

Pazopanib acts as an antineoplastic agent and a tyrosine kinase inhibitor, targeting vascular endothelial growth factor receptors and influencing angiogenesis. It treats patients with advanced renal cell carcinoma (RCC). Classified as an indazole, Pazopanib possesses a distinct chemical structure featuring a substituted pyrimidine and a sulfonamide group. It is primarily administered in its hydrochloride salt form to leverage its therapeutic effects. This medication is available under the trade name Votrient.

Pazopanib Structure and Mechanism of Action

The chemical name of Pazopanib is 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide. Its chemical formula is C₂₁H₂₃N₇O₂S, and its molecular weight is approximately 437.5 g/mol.

As an oral small-molecule multi-kinase inhibitor, Pazopanib predominantly inhibits vascular endothelial growth factor receptors 1, 2, and 3, platelet endothelial growth factor receptors 1, 2, and 3, and the cytokine receptor kit.

Pazopanib Impurities and Synthesis

Impurities can occur during the synthesis¹ of Pazopanib by mechanisms, including incomplete reactions, side reactions, and the contaminants in the starting materials or reagents. Strict quality control measures are needed while preparing Pazopanib to avoid unwanted side effects caused by these impurities.

Daicel Pharma offers a Certificate of Analysis (CoA) for Pazopanib impurity standards that involve Pazopanib Dimer, Pazopanib Impurity 9, Pazopanib impurity 8, Pazopanib N-oxide (RRT-0.70), Pazopanib Pyrimidine impurity and more. Our CoA is from our cGMP-certified analytical laboratory and includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². More characterization details, such as those for 13C-DEPT, can be provided on request. Our team of professionals at Daicel Pharma specializes in providing Pazopanib impurities and degradation compounds for testing the efficacy of generic Pazopanib. We provide Pazopanib-d3, a deuterium-labeled Pazopanib standard essential for bioanalytical research and Bioavailability/Bioequivalence (BA/BE) studies.