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Methods such as gradient Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) and preparative HPLC can detect impurities in Salmeterol.
Yes, impurities in Salmeterol can impact patient safety. Depending on their nature and concentration, contaminants can cause adverse effects or reduce the efficacy of the medication.
Methanol achieves optimal solubility and separation of Salmeterol impurities. However, the choice of solvent depends on the specific impurity analyzed and the analytical technique employed.
Salmeterol impurities should be stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).
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