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The common impurities found in Somatostatin include truncated Somatostatin peptides, oxidized Somatostatin, and N-terminal modified Somatostatin.
The Common impurities found during Somatostatin synthesis include incomplete coupling of amino acids, racemization of amino acids, and deletion sequences in the final peptide.
Somatostatin impurities are detected using analytical techniques such as high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), etc.
Somatostatin impurities may be removed from the drug by various purification techniques such as HPLC, size exclusion chromatography, and reverse-phase chromatography.
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