Stiripentol
General Information
Stiripentol Impurities and Stiripentol
Daicel Pharma offers the best quality Stiripentol impurities, such as Stiripentol tert-alcohol impurity. It is vital for evaluating Stiripentol quality, stability, and biological safety. Furthermore, Daicel Pharma specializes in the custom synthesis of Stiripentol impurities and ensures their worldwide delivery.
Stiripentol [CAS: 49763-96-4] treats seizures associated with Dravet syndrome (DS) in patients taking the drug clobazam. It is an orphan antiepileptic drug that treats severe myoclonic epilepsy in infancy (SMEI), along with other antiepileptics.
Stiripentol: Use and Commercial Availability
Stiripentol treats seizures in patients whose symptoms are uncontrolled by other drugs like clobazam and valproate. It has anticonvulsant properties that treat patients with Dravet syndrome (DS). Stiripentol aids in a rare form of childhood epilepsy. It is administered orally to patients. Stiripentol is available as Diacomit
Stiripentol Structure and Mechanism of Action
The chemical name of Stiripentol is (E)-1-(1,3-Benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol. The chemical formula for Stiripentol is C14H18O3, and its molecular weight is approximately 234.29 g/mol.
Stiripentol modulates the gamma-aminobutyric acid (GABA)A receptors. In addition, it blocks cytochrome P450 activity.
Stiripentol Impurities and Synthesis
During the synthesis of Stiripentol 1, impurities may form that may affect the safety and efficacy of the drug. These impurities form during the synthesis, storage, or degradation of Stiripentol. So, Stiripentol impurities must be controlled and monitored throughout the drug’s lifecycle.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Stiripentol impurities, which includes Stiripentol tert-alcohol impurity. The issued CoA is from a cGMP-compliant analytical facility. It contains characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional spectral data on request. Daicel Pharma can prepare any unidentified Stiripentol impurity or degradation product. In addition, Daicel Pharma offers highly purified isotope-labeled standards of Stiripentol for bioanalytical research and BA/BE studies. We also provide a complete characterization report on delivery.
References
FAQ's
References
- Vallet, Francois M. J., 1-(3,4-Methylenedioxy-phenyl)-4,4-dimethyl-pent-1-en-3-ol, US3910959A, Oct 7, 1975, Unicler S. A (https://www.lens.org/lens/search/patent/list?q=US3910959)
- Darwish, Hany W.; Abdelhameed, Ali S.; Attia, Mohamed I. ; Bakheit, Ahmed H.; Khalil, Nasr Y.; Al-Majed, Abdulrahman A., A stability-indicating HPLC-DAD method for determination of stiripentol: development, validation, kinetics, structure elucidation and application to commercial dosage form, Journal of Analytical Methods in Chemistry, Pages: 638951/1-638951/10, 11 pp., 2014 DOI: (10.1155/2014/638951)
Frequently Asked Questions
Which method helps to analyze and identify Stiripentol Impurities and degradation products?
RP-HPLC method helps to analyze and identify Stiripentol Impurities and degradation products.
How do Stiripentol degradation products form?
Stiripentol degradation products form due to oxidation, acid/base hydrolysis, and light radiation on Stiripentol.
What happens if Stiripentol Impurities remain in the drug?
Stiripentol Impurities can adversely affect drug safety and efficacy if they remain in the final drug.
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