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Teriparatide
References
FAQ's
References
- Tregear, Geoffrey W.; Van Rietschoten, Jurphaas; Greene, Elizabeth; Niall, Hugh D.; Keutmann, Henry T.; Parsons, John A.; O'Riordan, Jeffrey L. H.; Potts, John T. Jr., “Solid-phase synthesis of the biologically active N-terminal 1-34 peptide of human parathyroid hormone”, Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, Volume: 355, Issue: 4, Pages: 415-21,1974 DOI
- WANG, Wei, JIANG,Xuban, YIN, Chuanlong, ΤΑΟ, Anjin, YU，Pinxiang, Hybio Pharmaceutical Co., Ltd, “Teriparatide Impurity F” PCT application, WO2021114788A1, June 17, 2021
- Kothari, Ruchi; Kumar, Vinod; Jena, Rajender; Tunga, Rashbehari; Tunga, Binita Shrivastava, “Modes of degradation and impurity characterization in rhPTH (1-34) during stability studies”, PDA Journal of Pharmaceutical Science and Technology, Volume: 65, Issue: 4, Pages
- Chansel, D.; Sraer, J.; Morgat, J. L.; Hesch, R. D.; Ardaillou, R., “Preparation of biologically active tritium-labeled 1-34 human parathyroid hormone”, FEBS Letters, Volume: 78, Issue: 2, Pages: 237-43, 1977
Frequently Asked Questions
How are Teriparatide impurities synthesized?
The synthesis of Teriparatide impurities involves a variety of chemical reactions, such as oxidation, reduction, hydrolysis, and esterification. The synthetic pathways will depend on the study of the specific impurities.
What are the analytical techniques used to identify Teriparatide impurities?
Analytical techniques such as high-performance liquid chromatography (HPLC), and liquid chromatography mass spectrometry (LC-MS) help to identify Teriparatide impurities.
How are Teriparatide impurities removed from the drug?
Teriparatide impurities can be removed from the drug using various purification techniques such as chromatography, filtration, and extraction. These techniques help to isolate and remove impurities from Teriparatide.
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