Varenicline -SIL NDSRI
References
FAQ's
References
- Coe, Jotham Wadsworth; Brooks, Paige Roanne Palmer, Aryl Fused Azapolycyclic Compounds, Pfizer Products Inc., EP1044189B1, February 13, 2008
- Satheesh, B.; Kumarpulluru, S.; Raghavan, V.; Saravanan, D., UPLC separation and quantification of related substances of varenicline tartrate tablet, Acta Chromatographica, Volume: 22, Issue: 2, Pages: 207-218, 2010
Frequently Asked Questions
How does HPLC detect Varenicline impurities?
HPLC separates impurities based on their chemical and physical properties, such as molecular weight, polarity, and charge. The separated impurities are then detected using a UV detector or a mass spectrometer.
What is the role of mass spectrometry in the analysis of Varenicline impurities?
Mass spectrometry is a sensitive technique that can detect and quantify impurities in Varenicline at low levels. It provides information on the molecular weight and structure of the impurities that helps in their identification and characterization.
Which solvent helps in the analysis of Varenicline impurities?
Methanol or Acetonitrile is a solvent used in analyzing many impurities in Varenicline.
What are the temperature conditions required to store Varenicline impurities?
Varenicline impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).
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